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Chronic Cholestatic Liver Disease

Signs & Symptoms

 Itching preceding of jaundice
Ref: Harrison [ 2333]
Fatigue
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Pruritus
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]

Physical Examination

Lab / Serology

 Elevated Hepatic copper levels
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Elevated urinary copper levels
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Reduced serum ceruloplasmin
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]

Imagin Study

Complication

 Vitamin K deficiency
Note: fat soluble vitamin deficiencies
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Fatigue
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Steatorrhea
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]

Risk Factors

Cause

Other