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Primary Biliary Cirrhosis

 Syn. PBC , Primary Biliary Cholangitis , biliary cirrhosis primary

Signs & Symptoms

 Paresthesia in entire hand
Ref: Harrison [ 2333]
Symptoms of temporal lobe seizures
Ref: Harrison [ 2333]
Abdominal distention
Ref: Harrison [ 2332]
Increased need for sleep
Ref: Harrison [ 2333]

Physical Examination

 Abdominal distention
Ref: Harrison [ 2332]
Afternoon fatigue
Ref: Harrison [ 2333]
Fatigue after activity
Ref: Harrison [ 2333]

Lab / Serology

 Positive Antimitochondrial antibodies #Criteria
Note: 10% of patients with PBC may be AMA-negative
Ref: Uptodate [ Clinical manifestations, diagnosis, and natural history of primary biliary cirrhosis] Harrison [ 2335] Harrison [ 2408] Cecil [ 442]
Positive Antinuclear antibodies
Ref: Uptodate [ Clinical manifestations, diagnosis, and natural history of primary biliary cirrhosis]
Elevated Immunoglobulins
Ref: Harrison [ 2408]

Imagin Study

 Hepatomegaly
Ref: Uptodate [ Clinical manifestations, diagnosis, and natural history of primary biliary cirrhosis] Harrison [ 2408]
Abnormal EEG
Ref: Uptodate [ Alcoholic hepatitis: Clinical manifestations and diagnosis]
Imaging study reveal surface nodularity
Ref: Cecil [ 459]

Complication

 Abnormal EEG
Ref: Uptodate [ Alcoholic hepatitis: Clinical manifestations and diagnosis]
Amnesia
Ref: Cecil [ 464]
Anxiety
Ref: Epocrates [ https://online.epocrates.com/diseases/101031/Acute-liver-failure/Diagnostic-Approach]

Risk Factors

 Female
Ref: Unknown [ 0]
Intravenous drug use
Ref: Epocrates [ https://online.epocrates.com/diseases/27832/Cirrhosis/Risk-Factors]
Obesity
Ref: Epocrates [ https://online.epocrates.com/diseases/27832/Cirrhosis/Risk-Factors]

Cause

 hepatitis C
Ref: Cecil [ 458]
Nonalcoholic fatty liver disease
Ref: Cecil [ 458]
hepatitis B
Note: in Asia and in most of Africa
Ref: Cecil [ 458]

Other