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Hypogammaglobulinemia

Signs & Symptoms

 Positive family history of Primary hypogammaglobulinemia
Ref: Epocrates [ https://online.epocrates.com/diseases/105832/Hypogammaglobulinemia/Risk-Factors]
Hematologic malignancies
Ref: Epocrates [ https://online.epocrates.com/diseases/105832/Hypogammaglobulinemia/Risk-Factors]
Chemotherapy #Secondary_hypogammaglobulinemia
Ref: Epocrates [ https://online.epocrates.com/diseases/105811/Hypogammaglobulinemia/Highlights-Basics]
Repeated antibiotic use
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]

Physical Examination

 Rhonchi
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]
High-pitched inspiratory squeaks
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]
Respiratory crackles
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]

Lab / Serology

 Reduced Hb
Ref: Epocrates [ https://online.epocrates.com/diseases/105834/Hypogammaglobulinemia/Diagnostic-Tests]
Reduced lymphocytes
Note: due to common variable immunodeficiency, due to CVID, due to severe combined immunodeficiency
Ref: Epocrates [ https://online.epocrates.com/diseases/105834/Hypogammaglobulinemia/Diagnostic-Tests]
Elevated lymphocytes
Note: due to hematologic malignancy
Ref: Epocrates [ https://online.epocrates.com/diseases/105834/Hypogammaglobulinemia/Diagnostic-Tests]

Imagin Study

 Bronchiectasis
Note: due to recurrent pulmonary infection
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]
Chronic damage of sinuses
Note: due to recurrent sinuses infection
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]
Pneumatoceles
Note: due to hyper-IgE syndrome
Ref: Epocrates [ https://online.epocrates.com/diseases/105834/Hypogammaglobulinemia/Diagnostic-Tests]

Complication

 Bronchiectasis
Note: due to recurrent pulmonary infection
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]
Chronic damage of tympanic membrane
Note: due to recurrent ear infection
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]
Chronic damage of sinuses
Note: due to recurrent sinuses infection
Ref: Epocrates [ https://online.epocrates.com/diseases/105833/Hypogammaglobulinemia/History-Exam]

Risk Factors

 Male
Ref: Epocrates [ https://online.epocrates.com/diseases/105832/Hypogammaglobulinemia/Risk-Factors]

Cause

 Common variable immunodeficiency #Primary_hypogammaglobulinemia
Ref: Epocrates [ https://online.epocrates.com/diseases/105811/Hypogammaglobulinemia/Highlights-Basics]
Immunosuppressive drugs
Ref: Epocrates [ https://online.epocrates.com/diseases/105832/Hypogammaglobulinemia/Risk-Factors]
Chemotherapy #Secondary_hypogammaglobulinemia
Ref: Epocrates [ https://online.epocrates.com/diseases/105811/Hypogammaglobulinemia/Highlights-Basics]

Other