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Cryptococcosis

Signs & Symptoms

 Productive cough #pulmonary_cryptococcosis
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis] Epocrates [ https://online.epocrates.com/diseases/91733/Cryptococcosis/History-Exam]
Weight loss
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis] Epocrates [ https://online.epocrates.com/diseases/91733/Cryptococcosis/History-Exam]
Dyspnea #pulmonary_cryptococcosis
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis] Uptodate [ https://online.epocrates.com/diseases/91733/Cryptococcosis/History-Exam]
Chest pain #pulmonary_cryptococcosis
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis] Epocrates [ https://online.epocrates.com/diseases/91733/Cryptococcosis/History-Exam]

Physical Examination

 Optic disc swelling
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Brain involvement
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Papilledema
Note: due to Increased intracranial pressure, due to Elevated ICP, due to meningeal inflammation, due to cryptococcoma, due to hydrocephalus
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]

Lab / Serology

 CD4 plus lymphopenia
Ref: Uptodate [ Cryptococcus gattii infection: Microbiology, epidemiology, and pathogenesis]
Positive CGB agar
Note: With C. gattii
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Slightly low CSF glucose
Note: lumber puncture
Ref: Epocrates [ https://online.epocrates.com/diseases/91732/Cryptococcosis/Risk-Factors]

Imagin Study

 Cryptococcomas of lungs #C_gattii
Note: as single lesions, can mimic neoplastic disease
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Involvement of the right upper lobe of lung
Note: With Pancoast syndrome
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Cryptococcomas of brain
Note: as single lesions, can mimic neoplastic disease
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]

Complication

 Brain ischemia
Note: due to Increased intracranial pressure, due to Elevated ICP
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Death
Note: due to Increased intracranial pressure, due to Elevated ICP, due to brain ischemia
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]
Neurologic deficits
Note: due to Increased intracranial pressure, due to Elevated ICP
Ref: Uptodate [ Cryptococcus gattii infection: Clinical features and diagnosis]

Risk Factors

 Smoking
Ref: Uptodate [ Cryptococcus gattii infection: Microbiology, epidemiology, and pathogenesis]
Male
Ref: Epocrates [ https://online.epocrates.com/diseases/91732/Cryptococcosis/Risk-Factors]
Postpartum period
Ref: Epocrates [ https://online.epocrates.com/diseases/91732/Cryptococcosis/Risk-Factors]

Cause

Other