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Disseminated Intravascular Coagulation

 Syn. DIC , Consumption coagulopathy , Defibrination syndrome

Signs & Symptoms

 Major trauma
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults] Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
CNS trauma
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults] Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
Burn
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults] Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
Severe obstetric disorders
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults] Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]

Physical Examination

 Hypotension
Note: due to shock
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults] Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
Tachycardia
Note: due to shock
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
Gangrene
Note: due to microvascular thrombosis, due to macrovascular thrombosis
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]

Lab / Serology

 Elevated fibrin-related marker
Ref: Epocrates [ https://online.epocrates.com/diseases/18411/Disseminated-intravascular-coagulation/Highlights-Basics]
Abnormal global coagulation tests
Ref: Epocrates [ https://online.epocrates.com/diseases/18411/Disseminated-intravascular-coagulation/Highlights-Basics]
Azotemia
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]

Imagin Study

 Gastrointestinal ulcers
Note: Ischemic findings
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]

Complication

 Delirium
Note: due to microvascular thrombosis, due to macrovascular thrombosis
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
Coma
Note: due to microvascular thrombosis, due to macrovascular thrombosis
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]
Multiorgan ischemia
Note: due to Microvascular thrombosis
Ref: Epocrates [ Https://online.epocrates.com/diseases/184/Disseminated-intravascular-coagulation]

Risk Factors

Cause

 Heat stroke
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults]
Crush injuries
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults]
Amphetamine overdose
Ref: Uptodate [ Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults]

Other