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Endometrial Cancer

Signs & Symptoms

 Exogenous estrogen therapy
Note: in premenopausal and postmenopausal women
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Hormone replacement therapy
Note: in premenopausal and postmenopausal women
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Anovulation
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Nulliparity
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]

Physical Examination

 Adnexal mass
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Uterine mass
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Fixed uterus
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]

Lab / Serology

 Unopposed exogenous estrogen
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Unopposed endogenous estrogen
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Atypical glandular cells on cervical cytology
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]

Imagin Study

 Increased endometrial thickness
Note: >5mm
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Uterine polyps
Note: Involves the transcervical injection of sterile fluid (e.g., normal saline) into the uterine cavity during real-time ultrasound scanning of the endometrium
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Uterine enlargement
Note: Involves the transcervical injection of sterile fluid (e.g., normal saline) into the uterine cavity during real-time ultrasound scanning of the endometrium
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]

Complication

 Serum creatinine elevated
Note: due to renal system involvement, due to renal obstruction
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Elevated alkaline phosphatase
Note: due to metastatic spread to bones, due to metastatic spread to liver
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]
Round lung lesions
Note: due to lung metastases
Ref: Epocrates [ https://online.epocrates.com/diseases/26611/Endometrial-cancer/Highlights-Basics]

Risk Factors

 Age greater than 50
Ref: Epocrates [ https://online.epocrates.com/diseases/26632/Endometrial-cancer/Risk-Factors]
Overweight
Ref: Epocrates [ https://online.epocrates.com/diseases/26632/Endometrial-cancer/Risk-Factors]
Obesity
Ref: Epocrates [ https://online.epocrates.com/diseases/26632/Endometrial-cancer/Risk-Factors]

Cause

Other