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Amyloidosis

Signs & Symptoms

 Impaired coagulation
Ref: Uptodate [ Overview of amyloidosis]
Infiltration of the subcutaneous fat
Ref: Uptodate [ Overview of amyloidosis]
Hearing loss
Ref: Uptodate [ Overview of amyloidosis]
Visual loss #heritable_amyloidoses
Ref: Uptodate [ Overview of amyloidosis]

Physical Examination

 Infiltration of the subcutaneous fat
Ref: Uptodate [ Overview of amyloidosis]
Subcutaneous nodules
Ref: Uptodate [ Overview of amyloidosis]
Waxy thickening
Ref: Uptodate [ Overview of amyloidosis]

Lab / Serology

 Presence of monoclonal protein in urine immunofixation #AL_amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]
Presence of monoclonal protein in serum immunofixation #AL_amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]
Light chain protein in the urine #AL_amyloidosis
Note: due to multiple myeloma , due to amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]

Imagin Study

 Cardiac involvement with amyloid #AL_amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]
Thickening of the interventricular septum
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]
Restrictive filling of the ventricular chambers
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]

Complication

 Hearing loss
Ref: Uptodate [ Overview of amyloidosis]
Visual loss #heritable_amyloidoses
Ref: Uptodate [ Overview of amyloidosis]
Gross hematuria #heritable_amyloidoses
Ref: Uptodate [ Overview of amyloidosis]

Risk Factors

Cause

 Inflammatory polyarthropathy #AA_amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]
Rheumatoid arthritis #AA_amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]
Juvenile arthritis #AA_amyloidosis
Ref: Epocrates [ https://online.epocrates.com/diseases/44432/Amyloidosis/Risk-Factors]

Other