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Toxic Thyroid Adenoma

Signs & Symptoms

 Family history of thyroid nodules
Ref: Epocrates [ Toxic thyroid adenoma]
Neck irradiation
Note: Such as treatment for a malignancy e.g. lymphoma
Ref: Epocrates [ Toxic thyroid adenoma]
Weight loss
Note: due to Accelerated metabolism, due to higher basal metabolic rate, due to hyperthyroidism
Ref: Epocrates [ Toxic thyroid adenoma]
Head irradiation
Note: Such as treatment for a malignancy e.g. lymphoma
Ref: Epocrates [ Toxic thyroid adenoma]

Physical Examination

 Stare
Note: Stigma of Graves disease (exophthalmos) is absent
Ref: Epocrates [ Toxic thyroid adenoma]
Lid lag
Note: Stigma of Graves disease (exophthalmos) is absent
Ref: Epocrates [ Toxic thyroid adenoma]
Palpable thyroid nodule
Note: Nodule >3 cm, due to Hyperthyroid
Ref: Epocrates [ Toxic thyroid adenoma]

Lab / Serology

 Iodine deficiency
Note: Cause nodular goiter
Ref: Epocrates [ Toxic thyroid adenoma]
Urine iodine high (negative symptom)
Ref: Epocrates [ Toxic thyroid adenoma]
Suppressed TSH
Note: If not suppressed, toxic adenoma is essentially ruled out.
Ref: Epocrates [ Toxic thyroid adenoma]

Imagin Study

 Warm nodules
Note: Cold (i.e., nonfunctioning) or warm (i.e., isofunctioning) nodules >1 cm
Ref: Epocrates [ Toxic thyroid adenoma]
More-tall-than-wide shape nodules
Note: Cold (i.e., nonfunctioning) or warm (i.e., isofunctioning) nodules >1 cm
Ref: Epocrates [ Toxic thyroid adenoma]
Atrial fibrillation
Note: More common in older patients and may present with atrial fibrillation alone
Ref: Epocrates [ Toxic thyroid adenoma]

Complication

 Bone loss
Ref: Epocrates [ Toxic thyroid adenoma]
Cardiac dysfunction
Ref: Epocrates [ Toxic thyroid adenoma]
Neck compression
Ref: Epocrates [ Toxic thyroid adenoma]

Risk Factors

 20 < age < 40
Ref: Epocrates [ Toxic thyroid adenoma]
Female
Ref: Epocrates [ Toxic thyroid adenoma]

Cause

Other