Supporting Hours : Monday to Saturday - 8am to 10pm
New Visit

Multiple Endocrine Neoplasia 2b

 Syn. MEN2B

Signs & Symptoms

 Intestinal autonomic ganglion dysfunction #criteria
Note: cause multiple diverticulae, cause megacolon
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]
Mucosal neuromas eyelids #criteria
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]
Mucosal neuromas of tongue #criteria
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]
Medullated corneal fibers #criteria
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]

Physical Examination

 Decreased upper lower body ratio
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]
Marfanoid habitus #criteria
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]
Myelinated corneal nerves
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]

Lab / Serology

 Elevated catecholamines in urine
Note: 24-h Urinary free fractionated metanephrines (e.g., normetanephrine and metanephrines, due to Pheochromocytoma
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2753] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]
Pheochromocytoma #criteria
Note: 24-h Urinary free fractionated metanephrines (e.g., normetanephrine and metanephrines, p
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]
Higher levels of normetanephrine in urine
Note: 24-h Urinary free fractionated metanephrines (e.g., normetanephrine and metanephrines, due to Pheochromocytoma
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2753] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]

Imagin Study

Complication

 Coffee-ground vomit
Note: due to Zollinger-Ellison syndrome
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]
Gastrointestinal bleeding
Note: due to Zollinger-Ellison syndrome
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]
Melena
Note: due to Zollinger-Ellison syndrome
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]

Risk Factors

Cause

Other