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Multiple Endocrine Neoplasia 2a

 Syn. MEN2A

Signs & Symptoms

 Multicentric thyroid gland involvement
Note: due to Medullary thyroid cancer
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]
Flushing
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2753]
Scaly papular pigmented on extensor surfaces of the extremities
Note: due to Cutaneous lichen amyloidosis, due to CLA
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]
Upper third of the thyroid gland involvement
Note: due to Medullary thyroid cancer
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]

Physical Examination

 Scaly papular pigmented on interscapular region
Note: due to Cutaneous lichen amyloidosis, due to CLA
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]
Scaly papular pigmented on extensor surfaces of the extremities
Note: due to Cutaneous lichen amyloidosis, due to CLA
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]
Palpable thyroid nodule
Note: In the general population, between 7% to 15% of nodules are cancerous; the prevalence of medullary thyroid cancer is very low (0.4% to 1.4%).
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]

Lab / Serology

 Cervical lymphadenopathy
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]
Solitary thyroid nodule
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2]
Thyroid atypical cells
Note: Often early in life
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2753] Epocrates [ Https://online.epocrates.com/diseases/86634/Multiple-endocrine-neoplasia-syndromes/Diagnostic-Tests]

Imagin Study

 Colonic dilatation
Note: due to Hirschsprung disease, due to HD
Ref: Uptodate [ Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2] Harrison [ 2752]

Complication

 Coffee-ground vomit
Note: due to Zollinger-Ellison syndrome
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]
Gastrointestinal bleeding
Note: due to Zollinger-Ellison syndrome
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]
Hepatomegaly
Note: due to Liver metastasis
Ref: Epocrates [ Https://online.epocrates.com/diseases/86633/Multiple-endocrine-neoplasia-syndromes/History-Exam]

Risk Factors

Cause

Other