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Chronic Lymphocytic Leukemia

 Syn. CLL , Small Lymphocytic Lymphoma , SLL

Signs & Symptoms

 First-degree family member with SLL
Note: due to Genetic basis of disease, One of most familial-associated malignancies
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 763] Cecil [ 515]
First-degree family member with CLL
Note: due to Genetic basis of disease, One of most familial-associated malignancies
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 763] Cecil [ 515]
Family history of SLL
Note: due to Genetic basis of disease, One of most familial-associated malignancies
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 763] Cecil [ 515]
Family history of CLL
Note: due to Genetic basis of disease, One of most familial-associated malignancies
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 763] Cecil [ 515]

Physical Examination

 Axillary lymphadenopathy
Note: due to Infiltration of CLL cells in lymph nodes, Characteristically lymph nodes are firm, nontender and mobile
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 766] Cecil [ 516]
Supraclavicular lymphadenopathy
Note: due to Infiltration of CLL cells in lymph nodes, Characteristically lymph nodes are firm, nontender and mobile
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 766] Cecil [ 516]
Cervical lymphadenopathy
Note: due to Infiltration of CLL cells in lymph nodes, Characteristically lymph nodes are firm, nontender and mobile
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 766] Cecil [ 516]

Lab / Serology

 Lymphocytosis in peripheral blood #criteria, #CLL
Note: Absolute B lymphocyte count >5000
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 766] Cecil [ 516]
Lymphocytosis in bone marrow #CLL
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma]
Mildly increased blood lymphocytes #SLL
Note: Absolute lymphocyte count<5000 patients with nodal,splenic or other extramedullary involvement without cytopenias due to bone marrow infiltration are diagnosed with SLL
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma]

Imagin Study

Complication

 Hypogammaglobulinemia
Ref: Uptodate [ Overview of the complications of the chronic lymphocytic leukemia] Harrison [ 766] Cecil [ 516]
Membranoproliferative glomerulonephritis
Note: Due to Autoimmune complications
Ref: Uptodate [ Overview of the complications of chronic lymphocytic leukemia] Harrison [ 766]
Anemia
Note: due to Infiltration of CLL cells in the bone marrow, due to replacement of CLL cells in the bone marrow, due to bone marrow failure, due to autoimmune cytopenia
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma] Harrison [ 766] Cecil [ 516]

Risk Factors

 White race
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma]
Elder
Ref: Uptodate [ Clinical features and diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma]

Cause

Other