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Celiac Disease

 Syn. CD - Celiac disease , Coeliac sprue , nontropical sprue

Signs & Symptoms

 Abdominal pain after eating gluten
Ref: Uptodate [ History and physical examination in adults with abdominal pain]
Severe aphthous stomatitis
Ref: Epocrates [ https://online.epocrates.com/diseases/63631/Celiac-disease/Diagnostic-Approach]
Recurrent spontaneous abortion
Ref: Epocrates [ https://online.epocrates.com/diseases/63631/Celiac-disease/Diagnostic-Approach]
Recurrent severe aphthous stomatitis
Ref: Epocrates [ https://online.epocrates.com/diseases/63631/Celiac-disease/Diagnostic-Approach]

Physical Examination

 Weight loss
Ref: Uptodate [ Pathogenesis, epidemiology, and clinical manifestations of celiac disease in adults] Harrison [ 2251] Cecil [ 387]
Recurrent severe aphthous stomatitis
Ref: Epocrates [ https://online.epocrates.com/diseases/63631/Celiac-disease/Diagnostic-Approach]
Short stature
Ref: Epocrates [ https://online.epocrates.com/diseases/63631/Celiac-disease/Diagnostic-Approach]

Lab / Serology

 Elevated tissue transglutaminase-2
Ref: Uptodate [ Diagnosis of celiac disease in adults]
Positive transglutaminase IgA antibodies
Ref: Harrison [ 2949] Epocrates [ https://online.epocrates.com/diseases/63631/Celiac-disease/Diagnostic-Approach]
Abnormal small-intestinal biopsy
Ref: Harrison [ 2251]

Imagin Study

 Endoscopy show broad villi
Ref: Cecil [ 383]
Endoscopy show flattened villi
Ref: Cecil [ 383]

Complication

 Development of cancer
Ref: Harrison [ 2253]
Gastrointestinal neoplasms
Ref: Harrison [ 2253]
Nongastrointestinal neoplasms
Ref: Harrison [ 2253]

Risk Factors

 Family history of celiac disease
Ref: Epocrates [ https://online.epocrates.com/diseases/63632/Celiac-disease/Risk-Factors]
Immunoglobulin A deficiency
Ref: Epocrates [ https://online.epocrates.com/diseases/63632/Celiac-disease/Risk-Factors]
Type 1 diabetes
Ref: Epocrates [ https://online.epocrates.com/diseases/63632/Celiac-disease/Risk-Factors]

Cause

 Morphologic changes in the small-intestinal mucosa
Ref: Harrison [ 2244]
Mucosal malabsorption
Ref: Harrison [ 265]
Villous atrophy in proximal small bowel
Ref: Harrison [ 265]

Other