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Thrombotic Thrombocytopenic Purpura

 Syn. TTP

Signs & Symptoms

 Occurred in childhood (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Cancer therapies
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Recurrent nature of symptoms (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Diarrhea
Note: due to Microthrombi in the bowel, due to Escherichia coli infection
Ref: Uptodate [ Acquired TTP: Clinical manifestations and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]

Physical Examination

 Acutely ill (negative symptom)
Ref: Uptodate [ Acquired TTP: Clinical manifestations and diagnosi] Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
High blood pressure (negative symptom)
Note: Systolic BP >200 mmHg, diastolic BP >130 mmHg.
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Tachypnea (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]

Lab / Serology

 Decreased platelet count
Note: Platelet count of <20 x 10⁹/L is present in approximately 95% of patients
Ref: Uptodate [ Acquired TTP: Clinical manifestations and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Positive Direct Coombs (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Low hemoglobin level
Note: <8 g/L
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]

Imagin Study

 thrombosis in large vessels (negative symptom)
Ref: Uptodate [ Acquired TTP: Clinical manifestations and diagnosis]
Thyroid Involvement #Acquired_TTP
Ref: Uptodate [ Acquired TTP: Clinical manifestations and diagnosis]
Arrhythmia #Acquired_TTP
Note: due to Microthrombi in small arterioles or capillaries
Ref: Uptodate [ Acquired TTP: Clinical manifestations and diagnosis]

Complication

Risk Factors

 Female
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]
Obesity
Ref: Epocrates [ Acquired TTP: Clinical manifestations and diagnosis]
Age between 30 and 50
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]

Cause

 Pregnancy Gr. Female
Note: 75% of these episodes occurring around the time of delivery
Ref: Epocrates [ Https://online.epocrates.com/diseases/715/Thrombotic-thrombocytopenic-purpura]

Other