Supporting Hours : Monday to Saturday - 8am to 10pm
New Visit

Familial Mediterranean Fever

 Syn. FMF

Signs & Symptoms

 Abdominal pain precedes fever #criteria
Note: Initially localized and then progress to become generalized, usually precedes fever and last longer,due to Peritoneal inflammation,due to inflammation of peritoneum,due to peritoneitis
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Key factors]
Initially localized and then progress to become generalized abdominal pain #criteria
Note: Initially localized and then progress to become generalized, usually precedes fever and last longer,due to Peritoneal inflammation,due to inflammation of peritoneum,due to peritoneitis
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Key factors]
Episodic abdominal pain #criteria
Note: Initially localized and then progress to become generalized, usually precedes fever and last longer,due to Peritoneal inflammation,due to inflammation of peritoneum,due to peritoneitis
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Key factors]
Sudden attacks of articular pain #criteria
Note: Usually monoarticular,involving one large joint(knee,ankle,hip)
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Vignette/key factors]

Physical Examination

 Initially localized and then progress to become generalized abdominal pain #criteria
Note: Initially localized and then progress to become generalized, usually precedes fever and last longer,due to Peritoneal inflammation,due to inflammation of peritoneum,due to peritoneitis
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Key factors]
Abdominal tenderness
Note: May initially be localized and then progress to become generalized,due to Peritoneal inflammation,due to inflammation of peritoneum,due to peritoneitis
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Vignette/key factors]
Abdominal guarding
Note: due to Peritoneal inflammation,due to inflammation of peritoneum,due to peritoneitis
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Vignette/key factors]

Lab / Serology

 High Nucleated white cell count (negative symptom)
Note: Nucleated white cell count between 200 to > 100000
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever]
Bacterial growth (negative symptom)
Note: Nucleated white cell count between 200 to > 100000
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever]
Positive rheumatoid factor (negative symptom)
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever]

Imagin Study

 Pleural effusion
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ Tests]
Abdominal fluid
Ref: Epocrates [ Tests]
Pericardial effusion
Ref: Epocrates [ Tests]

Complication

 Progressive nephropathy
Note: Rarely as first and only manifestation
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ key highlight/vignette]
Nephrotic syndrome
Note: Rarely as first and only manifestation
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ key highlight/vignette]
Secondary renal amyloidosis
Note: Rarely as first and only manifestation
Ref: Uptodate [ Clinical manifestations and diagnosis of familial mediterranean fever] Epocrates [ key highlight/vignette]

Risk Factors

 Male
Ref: Epocrates [ Epidemiology]
Mediterranean ancestry
Ref: Epocrates [ FMF: key highlihts]

Cause

 Mediterran fever gene mutations
Note: Autosomal recessive
Ref: Uptodate [ Familial Mediterranean fever: epidemiology ,genetics,and pathogenesis] Epocrates [ FMF:etiology]

Other