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Immune Thrombocytopenia

 Syn. ITP , Immune thrombocytopenic purpura , Idiopathic thrombocytopenic purpura

Signs & Symptoms

 Bleeding
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Bruising
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Petechiae
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Hemorrhagic bullae
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]

Physical Examination

 Platelet-type bleeding
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Delayed visceral bleeding (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Palpable spleen (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]

Lab / Serology

 Platelet-type bleeding
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis] Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Normal WBC
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Normal RBC
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]

Imagin Study

 Positive Helicobacter pylori breath test (negative symptom)
Note: Should be performed in areas with a high prevalence of H pylori infection
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Delayed visceral bleeding (negative symptom)
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Abnormal renal function (negative symptom) Gr. children
Ref: Uptodate [ Immune thrombocytopenia (ITP) in adults: Clinical manifestations and diagnosis]

Complication

 End organ damage (negative symptom)
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis]

Risk Factors

 Reproductive age
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Elder
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]
Age < 10
Ref: Epocrates [ Https://online.epocrates.com/diseases/138/Immune-thrombocytopeni]

Cause

 Preceding viral illness Gr. children
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis]
MMR vaccine Gr. children
Ref: Uptodate [ Immune thrombocytopenia (ITP) in children: Clinical features and diagnosis]

Other