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Recurrent Aphthous Stomatitis

 Syn. Canker sores , RAS

Signs & Symptoms

 High socioeconomic status
Ref: Epocrates [ Oral aphthous ulcer]
Fever (negative symptom)
Note: Associated to PFAPA
Ref: Uptodate [ Recurrent aphthous stomatitis] Epocrates [ Oral aphthous ulcer]
Malise (negative symptom)
Ref: Uptodate [ Recurrent aphthous stomatitis]
Weight loss (negative symptom)
Ref: Uptodate [ Recurrent aphthous stomatitis]

Physical Examination

 Peripheral neuropathy
Note: The role of vitamin supplementation in the treatment of RAS remains uncertain
Ref: Uptodate [ Recurrent aphthous stomatitis]
Plum-colored skin lesions (negative symptom)
Ref: Epocrates [ Oral aphthous ulcer]

Lab / Serology

 Folate deficiency
Ref: Uptodate [ Recurrent aphthous stomatitis] Epocrates [ Oral aphthous ulcer]
Iron deficiency
Note: Shortness of breath, Pallor, fatigue, weakness, decreased exercise tolerance
Ref: Uptodate [ Recurrent aphthous stomatitis] Epocrates [ Oral aphthous ulcer]
Vitamin B12 deficiently
Note: The role of vitamin supplementation in the treatment of RAS remains uncertain
Ref: Uptodate [ Recurrent aphthous stomatitis]

Imagin Study

 aortitis (negative symptom)
Note: MAGIC syndrome has overlap with Behçet syndrome
Ref: Uptodate [ Recurrent aphthous stomatitis]
Inflamed cartilage (negative symptom)
Note: MAGIC syndrome has overlap with Behçet syndrome
Ref: Uptodate [ Recurrent aphthous stomatitis]

Complication

 Small superficial ulcers of the oral mucosa (negative symptom)
Note: due to Epstein-Barr virus infection, due to EBV infection
Ref: Epocrates [ Oral aphthous ulcer]

Risk Factors

 White race
Ref: Epocrates [ Oral aphthous ulcer]
Children
Ref: Epocrates [ Oral aphthous ulcer]
Female
Ref: Epocrates [ Oral aphthous ulcer]

Cause

 Immune dysregulation
Note: due to Exaggerated proinflammatory process ,due to relatively weak anti-inflammatory response
Ref: Uptodate [ Recurrent aphthous stomatitis]
Vitamin B12 deficiently
Note: The role of vitamin supplementation in the treatment of RAS remains uncertain
Ref: Uptodate [ Recurrent aphthous stomatitis]
Nicorandil
Note: Drug-induced mucosal ulcers
Ref: Uptodate [ Recurrent aphthous stomatitis]

Other