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Androgenetic Alopecia

 Syn. Androgenic alopecia

Signs & Symptoms

 Menopause Gr. Female
Ref: Uptodate [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis , Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
Yellow dots
Ref: Uptodate [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis , Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
Deepening of voice Gr. Female
Ref: Uptodate [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]
Family history of hair loss Gr. Female
Ref: Uptodate [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]

Physical Examination

 Reduction in terminal hair density on the scalp Gr. Male
Note: Typically begins in the temporal scalp, midfrontal scalp, or vertex area of the scalp
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
Thinning of hair over the scalp
Ref: Uptodate [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis , Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
Hair follicle miniaturization
Note: due to shortened anagen phase
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]

Lab / Serology

 Mild perifollicular fibrosis
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]
Hyperandrogenic state Gr. Female
Note: due to Polycystic ovarian syndrome, due to hormonal abnormality
Ref: Uptodate [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]
Reduction of terminal to vellus hair follicles Gr. Male
Note: The T:V ratio is reduced from 7:1 to less than 2.5:1 in more advanced cases
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]

Imagin Study

 Scale (negative symptom)
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]

Complication

 Body dysmorphic disorder Gr. Male
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]
Psychosocial effect Gr. Male
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]
Stress related to hair loss Gr. Male
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]

Risk Factors

 Obesity
Ref: Epocrates [ Female pattern hair loss (androgenetic alopecia in females): Pathogenesis, clinical features, and diagnosis]
Puberty
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
Elder
Ref: Epocrates [ https://www.epocrates.com/online/diseases/223/androgenetic-alopecia]

Cause

 Androgens Gr. Male
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
DHT Gr. Male
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]
Dihydrotestosterone Gr. Male
Ref: Uptodate [ Androgenetic alopecia in males: Pathogenesis, clinical features, and diagnosis]

Other