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Acute Lymphoblastic Leukemia In Children
Signs & Symptoms
Oral bleeding
Note: due to Thrombocytopenia, due to coagulopathy
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Palpable spleen
Note: Splenomegaly is not exactly the same as palpable liver.maybe splenomegaly is present but it is not detected in the physical examination
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Palpable liver
Note: due to Hepatomegaly, Hepatomegaly is not exactly the same as palpable liver.maybe hepatomegaly is present but it is not detected in the physical examination
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Epistaxis
Note: due to Thrombocytopenia, due to coagulopathy
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Physical Examination
Clinically detectable splenomegaly
Note: Splenomegaly is not exactly the same as palpable liver.maybe splenomegaly is present but it is not detected in the physical examination
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Palpable liver
Note: due to Hepatomegaly, Hepatomegaly is not exactly the same as palpable liver.maybe hepatomegaly is present but it is not detected in the physical examination
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Palpable spleen
Note: Splenomegaly is not exactly the same as palpable liver.maybe splenomegaly is present but it is not detected in the physical examination
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Lab / Serology
Thrombocytopenia
Note: due to Bone marrow failure, due to infiltration of leukemic lymphoblasts, 75% of patients have platelete counts<100000
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Normochromic normocytic anemia
Note: due to Bone marrow failure, due to infiltration of leukemic lymphoblasts
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Decreased hemoglobin
Note: due to Bone marrow failure, due to infiltration of leukemic lymphoblasts
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Complication
Bone pain
Note: due to Infiltration of bone marrow with lymphoblasts, due to systemic inflammatory cytokines, Children with bone pain may present with a limp or refusal to bear weight
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Dyspnea
Note: due to superior vena cava syndrome, due to Upper airway obstruction, de to mediastinal mass, due to compressing trachea
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]
Joint pain
Note: due to Infiltration of bone marrow with lymphoblasts, due to systemic inflammatory cytokines, Children with bone pain may present with a limp or refusal to bear weight
Ref:
Uptodate
[ Overview of the clinical presentation and diagnosis of acute lymphoblastic leukemia/lymphoma in children]
Nelson
[ 603]