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Chronic Myeloid Leukemia

 Syn. CML , Chronic myelocytic leukemia , Chronic myelogenous leukemia

Signs & Symptoms

 Unexplained fever
Note: Patients in accelerated or blastic phase
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Harrison [ 751]
Joint pain
Note: Patients in accelerated or blastic phase, due to Rapid turnover of myeloid cells
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Cecil [ 475]
Bone pain
Note: Patients in accelerated or blastic phase, due to Rapid turnover of myeloid cells
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Cecil [ 751]
Lethargy
Ref: Uptodate [ Clinical manifestations and diagnosis of chronic myeloid leukemia] Cecil [ 475]

Physical Examination

 Left upper quadrant pain
Note: Specially in patients in accelerated phase or blast crisis, due to Splenomegaly, due to splenic infarction
Ref: Uptodate [ Clinical manifestations and diagnosis of chronic myeloid leukemia] Harrison [ 750] Cecil [ 475]
Infections
Note: Patients in accelerated or blastic phase
Ref: Harrison [ 751]

Lab / Serology

 Absolute Eosinophilia
Ref: Uptodate [ Clinical manifestations and diagnosis of chronic myeloid leukemia]
Circulating immature myeloid cells
Note: Typically<10% inchronic phase, 10-19% in accelerated phase and >20% in blast crisis
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment]
Leukocytosis
Note: Typically above 100000
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Harrison [ 751] Cecil [ 475] Epocrates [ https://www.epocrates.com/online/diseases/276/chronic-myeloid-leukemia#diagnostic-tests]

Imagin Study

 Abdominal mass
Note: Specially in patients in accelerated phase or blast crisis, due to Splenomegaly, due to splenic infarction
Ref: Uptodate [ Clinical manifestations and diagnosis of chronic myeloid leukemia] Harrison [ 750] Cecil [ 475]
Gastrointestinal hemorrhage
Note: Patients in accelerated or blastic phase, due to Platelet dysfunction
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment]
Gastrointestinal ulcers
Note: due to Basophilia induced histamine overproduction
Ref: Cecil [ 475]

Complication

 Thrombotic events
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Harrison [ 751]
Myocardial infarction
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Harrison [ 751]
Venous thrombosis
Ref: Uptodate [ Accelerated phase CML: diagnosis and treatment] Harrison [ 751]

Risk Factors

 Male
Ref: Epocrates [ https://www.epocrates.com/online/diseases/276/chronic-myeloid-leukemia#risk-factors]
Age between 65 and 74
Ref: Epocrates [ https://www.epocrates.com/online/diseases/276/chronic-myeloid-leukemia#risk-factors]

Cause

Other