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Central Diabetes Insipidus

 Syn. Central DI

Signs & Symptoms

 Polyuria
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus] Cecil [ 632] Epocrates [ https://www.epocrates.com/online/diseases/288/diabetes-insipidus#history-exam]
Ongoing stimulation of thirst
Note: due to High normal range serum sodium concentration
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus] Harrison [ 2685]
Nocturia
Note: due to Polyuria
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus] Harrison [ 2685] Cecil [ 632] Epocrates [ https://www.epocrates.com/online/diseases/288/diabetes-insipidus#history-exam]
Large volumes of dilute urine
Ref: Harrison [ 2685]

Physical Examination

 Respond to the synthetic analogue
Ref: Cecil [ 632]
Dehydration
Note: Unless thirst and/or the compensatory increase of fluid intake are also impaired
Ref: Harrison [ 2685]

Lab / Serology

 Decreased secretion AVP
Note: A decrease of 75% or more in the secretion AVP
Ref: Harrison [ 2685] Cecil [ 632]
Elevation in serum osmolality
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus] Harrison [ 2685]
Elevation in serum sodium
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus] Harrison [ 2685]

Imagin Study

 Decreased bone mineral density at the femoral neck
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus]
Decreased bone mineral density at the lumbar spine
Ref: Uptodate [ Clinical manifestations and causes of central diabetes insipidus]

Complication

Risk Factors

 Pregnant
Ref: Epocrates [ https://www.epocrates.com/online/diseases/288/diabetes-insipidus#risk-factors]

Cause

Other