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Graves Disease

Signs & Symptoms

 Skin lesion over lateral aspects of lower leg
Ref: Harrison [ 2704]
Skin lesion over anterior aspects of lower leg
Ref: Harrison [ 2704]
Hyperphagia
Ref: Uptodate [ Overview of the clinical manifestations of hyperthyroidism in adults]
Mimicking elephantiasis
Note: due to Nodular involvement
Ref: Harrison [ 2704]

Physical Examination

 Tremor
Ref: Uptodate [ Neurologic manifestations of hyperthyroidism and Graves' disease] Harrison [ 2704] Cecil [ 635]
Proximal muscle weakness
Ref: Uptodate [ Diagnosis of hyperthyroidism] Harrison [ 2704] Cecil [ 635]
Hypertension
Ref: Uptodate [ Overview of the clinical manifestations of hyperthyroidism in adults]

Lab / Serology

 Moderately elevated serum free T4
Ref: Uptodate [ Diagnosis of hyperthyroidism]
Low TSH
Ref: Uptodate [ Diagnosis of hyperthyroidism]
High T4
Ref: Uptodate [ Diagnosis of hyperthyroidism]

Imagin Study

 Enlarged extraocular muscles
Ref: Harrison [ 2704]
ECG myocardial ischemia
Ref: Uptodate [ Cardiovascular effects of hyperthyroidism]
Increase in left ventricular mass index
Ref: Uptodate [ Cardiovascular effects of hyperthyroidism]

Complication

 Ear pain
Note: due to Subacute thyroiditis
Ref: Harrison [ 2708]
Visual impairment
Ref: Cecil [ 636]
Sore throat
Note: due to Subacute thyroiditis
Ref: Harrison [ 2708]

Risk Factors

 Female
Ref: Uptodate [ Overview of the clinical manifestations of hyperthyroidism in adults]
Passive Smoking
Ref: Uptodate [ Overview of the clinical manifestations of hyperthyroidism in adults]
Smoking
Ref: Uptodate [ Overview of the clinical manifestations of hyperthyroidism in adults]

Cause

 Graves disease
Ref: Uptodate [ Disorders that cause hyperthyroidism]
Struma ovarii
Ref: Uptodate [ Disorders that cause hyperthyroidism]
Factitious ingestion of thyroid hormone
Ref: Uptodate [ Disorders that cause hyperthyroidism]

Other