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Systemic Sclerosis

 Syn. scleroderma

Signs & Symptoms

 Gastrointestinal involvement
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2555] Cecil [ 800]
Swelling of the hands
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2552] Cecil [ 788]
Stiffness
Ref: Harrison [ 2556]
Puffy fingers
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2552] Cecil [ 788]

Physical Examination

 Gastrointestinal involvement
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2555] Cecil [ 800]
Puffy fingers
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2552] Cecil [ 788]
Soft tissue swelling
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2552] Cecil [ 788]

Lab / Serology

 Positive Antinuclear autoantibodies
Ref: Harrison [ 2556]
Presence of to topoisomerase-I antibody #DcSSc
Note: More likely to have dcSSc
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2166.2554] Cecil [ 788]
positive SSc-associated serum antibodies (negative symptom)
Ref: Unknown [ Unknown]

Imagin Study

 Pulmonary involvement
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults]
Bibasilar fibrotic changes
Ref: Cecil [ 789]
Increased tricuspid regurgitation jet velocities
Note: Suggest pulmonary arterial pressure, Pulmonary artery systolic pressure >40 mmHg at rest , or tricuspid regurgitation jet velocities >3 m/sec
Ref: Harrison [ 2554]

Complication

 Pulmonary involvement
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults]
Incompetence of the lower esophageal sphincter disease
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2555] Cecil [ 788]
Esophageal hypomotility
Ref: Uptodate [ Overview of the clinical manifestations of systemic sclerosis (scleroderma) in adults] Harrison [ 2555] Cecil [ 788]

Risk Factors

Cause

Other