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Primary Sclerosing Cholangitis

 Syn. PSC , Cholangitides, Primary Sclerosing , sclerosing cholangitis

Signs & Symptoms

 Abdominal distention
Ref: Harrison [ 2332]
Symptoms of temporal lobe seizures
Ref: Harrison [ 2333]
Poor appetite #Constitutional_symptoms
Ref: Harrison [ 2332]
Increased need for sleep
Ref: Harrison [ 2333]

Physical Examination

 Hyperpigmentation of skin
Ref: Harrison [ 2335]
Abdominal distention
Ref: Harrison [ 2332]
Afternoon fatigue
Ref: Harrison [ 2333]

Lab / Serology

 Positive antinuclear autoantibody
Note: uncertain clinical significance, positive for at least one autoantibody
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Positive antismooth muscle autoantibody
Note: uncertain clinical significance, positive for at least one autoantibody
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]
Positive anticardiolipin antibodies
Note: correlate with disease severity, correlated with the Mayo risk score, uncertain clinical significance, positive for at least one autoantibody
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis]

Imagin Study

 Ascites #GASTROINTESTINAL
Note: due to portal hypertension
Ref: Harrison [ 2411] Harrison [ Evaluation of adults with ascites] Cecil [ 459]
Relative enlargement of the left hepatic
Ref: Cecil [ 459]
Relative enlargement of the left hepatic and caudate lobes
Note: due to right lobe atrophy
Ref: Cecil [ 459]

Complication

 Complication ulcerative colitis
Note: colonoscopy should be performed to look for evidence of UC
Ref: Uptodate [ Clinical manifestations and diagnosis of primary sclerosing cholangitis] Harrison [ 2409] Cecil [ 474-475]
Dyspraxia
Ref: Epocrates [ https://online.epocrates.com/diseases/101031/Acute-liver-failure/Diagnostic-Approach]
Dizziness
Ref: Cecil [ 375]

Risk Factors

 Male
Ref: Epocrates [ https://online.epocrates.com/diseases/84732/Primary-sclerosing-cholangitis/Risk-Factors]
< 45 years old
Ref: Unknown [ 0]
Alcohol
Ref: Epocrates [ https://online.epocrates.com/diseases/27832/Cirrhosis/Risk-Factors] Unknown [ 0]

Cause

 alcoholic liver disease
Ref: Cecil [ 458]
hepatitis C
Ref: Cecil [ 458]
hepatitis B
Note: in Asia and in most of Africa
Ref: Cecil [ 458]

Other