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Malt Lymphoma

 Syn. MALToma

Signs & Symptoms

 History of Helicobacter pylori gastritis
Ref: Epocrates [ https://online.epocrates.com/diseases/87832/MALT-lymphoma/Risk-Factors]
Rheumatoid arthritis
Note: associated with MALT lymphoma of the lung
Ref: Epocrates [ https://online.epocrates.com/diseases/87832/MALT-lymphoma/Risk-Factors]
Lymphoepithelial sialadenitis
Note: associated with MALT lymphoma of the parotid gland
Ref: Epocrates [ https://online.epocrates.com/diseases/87832/MALT-lymphoma/Risk-Factors]
Dyspepsia
Note: due to gastritis
Ref: Epocrates [ https://online.epocrates.com/diseases/87832/MALT-lymphoma/Risk-Factors]

Physical Examination

 Nodules on upper extremities #Primary_cutaneous_marginal_zone_lymphoma
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]
Nodules on trunk #Primary_cutaneous_marginal_zone_lymphoma
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]
Nodules #Primary_cutaneous_marginal_zone_lymphoma
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]

Lab / Serology

 Chromosomal abnormalities
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]
Positive CD5 (negative symptom)
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]
Immunophenotype
Note: .B cell-associated antigens (CD19, CD20, CD22, CD79a) and complement receptors (CD21 and CD35), and are usually negative for CD5, CD10, CD23, BCL6, and cyclin D1
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]

Imagin Study

 Rapid tumor growth (negative symptom)
Note: Differentiation between EMZL and DLBCL is made primarily based upon morphologic features
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)] Harrison [ 302] Cecil [ 512]
Air space consolidation #EMZL_of_lung
Note: A potential link between pulmonary EMZL and Achromobacter xylosoxidans infection
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]
Thickening of the mucosal folds in the second part of the duodenum #Immunoproliferative_small_intestinal_disease
Note: Association of Campylobacter jejuni infection with IPSID has been suggested
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)] Harrison [ 298]

Complication

 Gastroesophageal reflux diseas #Gastric_EMZL
Note: due to Chronic gastritis in the presence of Helicobacter pylori, note to H. pylori-induced gastritis leads to the accumulation of CD4+ lymphocytes and mature B cells in the gastric lamina propria, Most patients (>90 percent) with gastric EMZL are H. pylori positive
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)] Harrison [ 298] Cecil [ 382,512]
Weight loss #Gastric_EMZL
Note: note to H. pylori-induced gastritis leads to the accumulation of CD4+ lymphocytes and mature B cells in the gastric lamina propria, Most patients (>90 percent) with gastric EMZL are H. pylori positive,due to Chronic gastritis in the presence of Helicobacter pylori
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)] Harrison [ 298] Cecil [ 382,512]
Epigastric pain #Gastric_EMZL
Note: note to H. pylori-induced gastritis leads to the accumulation of CD4+ lymphocytes and mature B cells in the gastric lamina propria, Most patients (>90 percent) with gastric EMZL are H. pylori positive,due to Chronic gastritis in the presence of Helicobacter pylori
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)] Harrison [ 298] Cecil [ 382,512]

Risk Factors

 Age > 60
Ref: Epocrates [ https://online.epocrates.com/diseases/87832/MALT-lymphoma/Risk-Factors]

Cause

 Chromosomal abnormalities
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]
Trisomy 3
Ref: Uptodate [ Clinical manifestations, pathologic features, and diagnosis of extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT)]

Other