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Breast Cancer

 Syn. Breast Malignancy , Breast Malignant Lesions , Breast Neoplasm

Signs & Symptoms

 Benign breast disease
Note: Proliferative breast lesions especially those with histologic atypia
Ref: Uptodate [ Factors that modify breast cancer risk in women] Cecil [ 602] Epocrates [ https://www.epocrates.com/online/diseases/716/primary-invasive-breast-cancer#history-exam]
Change in breast symmetry
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]
New onset headache #Metastatic_breast_cancer
Note: Brain metastasis
Ref: Cecil [ 603]
Shortness of breath #Metastatic_breast_cancer
Note: Lung metastasis
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]

Physical Examination

 Single breast masses
Note: These features cannot reliably distinguish a benign from a malignant tumor
Ref: Uptodate [ Factors that modify breast cancer risk in women] Harrison [ 557]
Change in breast size
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]
Supraclavicular adenopathy #Locally_advanced_disease, #locoregional_disease
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer] Cecil [ 603]

Lab / Serology

 Elevated alkaline phosphatase #Metastatic_breast_cancer
Note: Bone metastasis
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]
Elevated ALT #Metastatic_breast_cancer
Note: Liver metastasis
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]
Elevated AST #Metastatic_breast_cancer
Note: Liver metastasis
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]

Imagin Study

 Enhancing internal septa
Note: Nearly all
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]
High density mass
Note: Specially if the densities are spiculated
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer] Harrison [ 557]
Heterogeneous internal enhancement
Note: Nearly all
Ref: Uptodate [ Clinical features,diagnosis,and staging of newly diagnosed breast cancer]

Complication

Risk Factors

 Female
Ref: Cecil [ 606]
White race
Ref: Cecil [ 601]
Black ethnicity
Ref: Uptodate [ Factors that modify breast cancer risk in women]

Cause

Other