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Secondary Hypogonadism

 Syn. Hypogonadotropic hypogonadism

Signs & Symptoms

 Small phallus
Note: due to Low serum testosterone concentration, <8 cm
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism]
Low energy
Note: due to Low serum testosterone concentration
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism] Harrison [ 942] Cecil [ 715]
Small testes
Note: due to Low serum testosterone concentration, <20 mL
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism]
Low libido
Note: due to Low serum testosterone concentration
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism] Harrison [ 942] Cecil [ 715]

Physical Examination

 Eunuchoid proportions
Note: due to Low serum testosterone concentration, An arm span >2 cm greater than height
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism] Harrison [ 942]
Gynecomastia (negative symptom)
Note: due to Low serum testosterone concentration, More likely to occur in primary than secondary hypogonadism
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism] Harrison [ 942] Cecil [ 660]
Small phallus
Note: due to Low serum testosterone concentration, <8 cm
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism]

Lab / Serology

 Leptin
Ref: Uptodate [ Causes of secondary hypogonadism in males] Harrison [ 942]
Subnormal sperm count
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism] Harrison [ 944]
Beta-subunit of FSH
Ref: Uptodate [ Causes of secondary hypogonadism in males] Harrison [ 942]

Imagin Study

Complication

 Hot flashes
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism]

Risk Factors

 Male
Ref: Uptodate [ Clinical features and diagnosis of male hypogonadism]

Cause

 Congenital GnRH deficiency
Ref: Uptodate [ Causes of secondary hypogonadism in males] Harrison [ 942]
Isolated hypogonadotropic hypogonadism
Ref: Uptodate [ Causes of secondary hypogonadism in males] Harrison [ 942]
Syndromes associated with developmental delay
Ref: Uptodate [ Causes of secondary hypogonadism in males] Harrison [ 942]

Other