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Primary Hypogonadism
Syn.
Disease of the testes
, Hypergonadotropic hypogonadism
Signs & Symptoms
Trauma
Ref:
Uptodate
[
Causes of primary hypogonadism in males
]
Alkylating agents
Ref:
Uptodate
[
Causes of primary hypogonadism in males
]
Antineoplastic agents
Ref:
Uptodate
[
Causes of primary hypogonadism in males
]
Radiation
Note:
Damage is proportionate to the extent and duration of radiation
Ref:
Uptodate
[
Causes of primary hypogonadism in males
]
Physical Examination
Ambiguous genitalia
Note:
During the first trimester, results in female external genitalia
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Small testes
Note:
due to Low serum testosterone concentration,<20 mL
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Eunuchoid proportions
Note:
due to Low serum testosterone concentration, An arm span >2 cm greater than height
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Harrison
[
942
]
Lab / Serology
Low Serum total testosterone
Note:
Lower than 300ng/dl in the morning
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Harrison
[
942
]
Subnormal sperm count
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Harrison
[
944
]
47 XXY
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Harrison
[
941
]
Cecil
[
658
]
Imagin Study
Low bone mineral density
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Small phallus
Note:
due to Low serum testosterone concentration,<8 cm
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Decreased muscle mass
Note:
due to Low serum testosterone concentration
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Complication
Hot flashes
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Risk Factors
Male
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Obesity
Ref:
Harrison
[
930
]
Cause
Varicocele
Ref:
Uptodate
[
Causes of primary hypogonadism in males
]
Mumps
Note:
Median age of mumps orchitis is 29 years
Ref:
Uptodate
[
Causes of primary hypogonadism in males
]
47 XXY
Ref:
Uptodate
[
Clinical features and diagnosis of male hypogonadism
]
Harrison
[
941
]
Cecil
[
658
]
Other