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Cushing Syndrome

Signs & Symptoms

 Irritability
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]
Decreased libido
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Epocrates [ https://www.epocrates.com/online/diseases/205/cushing-syndrome#history-exam]
Progressive obesity
Note: note to Usually involving the face, neck, trunk, abdomen and, internally, spinal canal and mediastinum,due to Hypercortisolism
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680] Cecil [ 630]
Excess menses
Note: due to suppression of secretion of gonadotropin-releasing hormone , due to hypercortisolemia
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680]

Physical Examination

 Round face
Note: due to Hypercortisolism
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680]
Tinea versicolor
Note: note to Especially tinea versicolor,often found on the trunk
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]
Cutaneous fungal infections
Note: Especially tinea versicolor,often found on the trunk
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]

Lab / Serology

 Bacterial infections
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]
Abnormal glucose tolerance
Note: due to timulation of gluconeogenesis by cortisol, due to peripheral insulin resistance,due to obesity
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680]
Eosinopenia
Ref: Harrison [ 2680]

Imagin Study

 Spinal canal obesity
Note: due to Hypercortisolism
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680] Cecil [ 630]
Multiple fractures #Ectopic ACTH secretion
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]
Vertebral compression fractures
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]

Complication

 Vertebral compression fractures
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]
Hypercalciuria
Note: due to Increased bone resorption
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]
Renal calculi
Note: due to Increased bone resorption
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]

Risk Factors

 Female
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome]

Cause

 ACTH-secreting pituitary tumors
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680] Cecil [ 630]
Iatrogenic Cushing syndrome
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Harrison [ 2680]
Chronic exposure to excess glucocorticoid
Ref: Uptodate [ Epidemiology and clinical manifestations of Cushing's syndrome] Cecil [ 630]

Other