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Granulomatosis With Polyangiitis

 Syn. Wegeners granulomatosis , Wegener granulomatosis

Signs & Symptoms

 Pulmonary involvement
Ref: Harrison [ 2578]
Meningeal disease
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]
Weakness
Ref: Harrison [ 2579]
Exposure to silica dust
Ref: Harrison [ 2140]

Physical Examination

 Crusting
Note: For more than one month
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis] Harrison [ 2140]
Purulent nasal discharge
Note: For more than one month
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis] Harrison [ 2140]
Edema
Note: due to Glomerulonephritis
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]

Lab / Serology

 Positive C-ANCA
Note: Especialy C-ANCA
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis] Harrison [ 2513] Cecil [ 795]
Positive ANCA
Note: Especialy C-ANCA
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis] Harrison [ 2513] Cecil [ 795]
Alpha 1-antitrypsin deficiency
Ref: Harrison [ 2140]

Imagin Study

 Upper airway mass
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]
Retro-orbital mass
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis] Cecil [ 795]
Cavity in lung
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis] Harrison [ 2140] Cecil [ 795]

Complication

 Severe permanent hearing impairment
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]
Permanent hearing impairment
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]
Severe hearing impairment
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]

Risk Factors

 Elder
Ref: Uptodate [ Clinical manifestations and diagnosis of granulomatosis with polyangiitis and microscopic polyangiitis]

Cause

Other