Supporting Hours : Monday to Saturday - 8am to 10pm
New Visit

Acromegaly

Signs & Symptoms

 Oily skin
Ref: Harrison [ 2678]
Skin thickening
Ref: Uptodate [ Causes and clinical manifestations of acromegaly]
Fatigue
Note: due to Sleep apnea, due to cardiovascular dysfunction, due to neuropathy, due to hypogonadism, due to hyperglycemia
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Hypertrophic arthropathy of the ankles
Note: due to Enlargement of synovial tissue and cartilage
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]

Physical Examination

 Weakness
Note: due to Sleep apnea, due to cardiovascular dysfunction, due to neuropathy, due to hypogonadism, due to hyperglycemia
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Diastolic dysfunction
Note: due to Cardiomyopathy
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Arrhythmias
Note: due to Cardiomyopathy
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]

Lab / Serology

 Hyperphosphatemia
Ref: Uptodate [ Causes and clinical manifestations of acromegaly]
Insulin resistance
Ref: Uptodate [ Causes and clinical manifestations of acromegaly]
Hypertriglyceridemia
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Cecil [ 628]

Imagin Study

 Multinodular Thyroid enlargement
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Diffuse Thyroid enlargement
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Thyroid enlargement
Note: May be diffuse or multinodular
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]

Complication

 Thyroid enlargement
Note: May be diffuse or multinodular
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Sleep apnea
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]
Upper airway obstruction
Note: due to Macroglossia, due to enlargement of the soft tissues of the pharynx, due to enlargement of the soft tissues of the larynx
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2678]

Risk Factors

Cause

 Persistent hypersecretion of growth hormone
Ref: Uptodate [ Diagnosis of acromegaly] Cecil [ 627]
Hepatic hypersecretion of insulin-like growth factor 1
Ref: Uptodate [ Diagnosis of acromegaly] Cecil [ 627]
Somatotroph adenoma of the anterior pituitary
Note: One-third of all hormone-secreting pituitary adenomas
Ref: Uptodate [ Causes and clinical manifestations of acromegaly] Harrison [ 2677]

Other