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Parkinson Disease

 Syn. Paralysis agitans

Signs & Symptoms

 Resting tremor
Ref: Uptodate [ Clinical manifestations of Parkinson disease] Harrison [ 3120]
Early morning awakening
Ref: Uptodate [ Clinical manifestations of Parkinson disease]
Tremor #Criteria
Ref: Uptodate [ Clinical manifestations of Parkinson disease]
Decreased manual dexterity of the fingers
Note: due to Bradykinesia in the arms
Ref: Uptodate [ Clinical manifestations of Parkinson disease]

Physical Examination

 Impairment of multi-tasking
Ref: Uptodate [ Clinical manifestations of Parkinson disease]
Bradykinesia #Criteria
Note: generalized slowness of movement
Ref: Uptodate [ Clinical manifestations of Parkinson disease] Harrison [ 3120]
Rigidity #Criteria
Note: Is an increased resistance to passive movement about a join
Ref: Uptodate [ Clinical manifestations of Parkinson disease] Harrison [ 3120]

Lab / Serology

Imagin Study

 Asymmetric uptake of striatal dopaminergic biomarkers
Note: PET or SPECT
Ref: Harrison [ 3121]
Reduced uptake of striatal dopaminergic biomarkers
Note: PET or SPECT
Ref: Harrison [ 3121]
Normal functional neuroimaging of the presynaptic dopaminergic system (negative symptom)
Ref: Uptodate [ Diagnosis and differential diagnosis of Parkinson disease]

Complication

 Sleep disorders
Ref: Uptodate [ Clinical manifestations of Parkinson disease]
Insomnia
Ref: Uptodate [ Clinical manifestations of Parkinson disease]
Early morning awakening
Ref: Uptodate [ Clinical manifestations of Parkinson disease]

Risk Factors

 Age greater than 60
Ref: Uptodate [ Clinical manifestations of Parkinson disease]
Male
Ref: Uptodate [ Etiology and pathogenesis of Parkinson disease]

Cause

Other