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Polyarteritis Nodosa

 Syn. PAN

Signs & Symptoms

 Hepatitis C virus
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]
Myalgia
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults] Harrison [ 2582]
Lower extremities skin lesions
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]
Hepatitis B virus
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]

Physical Examination

 Lower extremities skin lesions
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]
Muscle weakness
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults] Harrison [ 2582]
Diffused tender nodules
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]

Lab / Serology

 Necrotizing vasculitis
Note: Biopsy of small- or medium-sized artery containing polymorphonuclear cells
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults] Harrison [ 2583]
Positive ANCA (negative symptom)
Note: Strongly argues against PAN
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]
Leukocytosis
Ref: Harrison [ 2582]

Imagin Study

Complication

 Arthralgia
Ref: Harrison [ 2583]
Arthritis
Ref: Harrison [ 2583]
Bowel perforation
Note: due to Bowel infarction
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults] Harrison [ 2583]

Risk Factors

 Elder
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]
Middle aged
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]
Male
Ref: Uptodate [ Clinical manifestations and diagnosis of polyarteritis nodosa in adults]

Cause

Other