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Non-Alcoholic Fatty Liver Disease

 Syn. NAFLD , Fatty Liver, Nonalcoholic , Nonalcoholic Fatty Livers

Signs & Symptoms

 Fatigue #NASH
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults] Harrison [ 203]
Obstructive sleep apnea
Ref: Harrison [ 2403]
Mood alterations
Ref: Harrison [ 2403]
Vague pain
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults]

Physical Examination

 Associated with obesity
Ref: Harrison [ 2403] Cecil [ 545]
Stigmata of chronic liver disease
Ref: Harrison [ 2403]
Stigmata of portal hypertension #Advanced_NAFLD
Ref: Harrison [ 2403]

Lab / Serology

 Abnormal serum ferritin
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults]
Abnormal serum aminotransferases
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults]
AST to ALT ratio of less than one
Note: in some cases,AST is higher than the ALT, mimicking the pattern of alcoholic liver disease, AST/ALT ratio in NAFLD rarely exceeds 2
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults] Cecil [ 440]

Imagin Study

Complication

 Progress to cirrhosis #cirrhosis #Advanced_NAFLD
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults] Harrison [ 2843] Cecil [ 20]
Decreased Serum albumin #cirrhosis #Advanced_NAFLD
Note: abnormal in patients who have developed cirrhosis
Ref: Uptodate [ Epidemiology, clinical features, and diagnosis of nonalcoholic fatty liver disease in adults] Harrison [ 2403]
Progress to nonalcoholic steatohepatitis
Ref: Harrison [ 2843]

Risk Factors

 Diabetic
Ref: Unknown [ 0]
Dyslipidemia
Ref: Unknown [ 0]
40-50 age
Ref: Unknown [ 0]

Cause

 Associated with obesity
Ref: Harrison [ 2403] Cecil [ 545]
Associated with diabetes
Ref: Harrison [ 2403] Cecil [ 454]
Associated with hyperlipidemia
Ref: Cecil [ 454]

Other