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Guillain-Barre Syndrome

 Syn. Acute Inflammatory Demyelinating Polyneuropathy , Guillain Barre syndrome , GBS

Signs & Symptoms

 Depressed deep tendon reflexes #Criteria
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis] Cecil [ 1084]
Refusal to walk Gr. children
Note: In preschool-aged children
Ref: Uptodate [ Guillain-Barré syndrome in children: Epidemiology, clinical features, and diagnosis]
Pain in the legs Gr. children
Note: In preschool-aged children
Ref: Uptodate [ Guillain-Barré syndrome in children: Epidemiology, clinical features, and diagnosis]
Sensory abnormalities
Note: Sensory abnormalities on examination are frequently mild
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis] Cecil [ 1085]

Physical Examination

 Absent deep tendon reflexes #Criteria
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis] Cecil [ 1084]
Depressed deep tendon reflexes #Criteria
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis] Cecil [ 1084]
Symmetric muscle weakness
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]

Lab / Serology

 Elevated cerebrospinal fluid protein
Note: by Lumbar puncture, because Increased permeability of the blood-nerve-barrier at the level of the proximal nerve roots
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]
IgG antibodies to GQ1b
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]
CSF pleocytosis with elevated white cell count (negative symptom)
Note: CSF pleocytosis with a white cell count >50/mm3
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]

Imagin Study

 Electrodiagnostic study abnormality
Note: Typically most pronounced approximately two weeks after the onset of weakness
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]
Thickening of the intrathecal spinal nerve roots
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]
Thickening of the cauda equina
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]

Complication

 Bladder dysfunction Gr. children
Ref: Uptodate [ Guillain-Barré syndrome in children: Epidemiology, clinical features, and diagnosis]
Abnormal sweating Gr. children
Ref: Uptodate [ Guillain-Barré syndrome in children: Epidemiology, clinical features, and diagnosis]
Cardiac dysrhythmias Gr. children
Ref: Uptodate [ Guillain-Barré syndrome in children: Epidemiology, clinical features, and diagnosis]

Risk Factors

 Male
Ref: Uptodate [ Guillain-Barré syndrome in children: Epidemiology, clinical features, and diagnosis]

Cause

 Bone-marrow transplantation
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]
Trauma
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]
Surgery
Ref: Uptodate [ Guillain-Barré syndrome in adults: Clinical features and diagnosis]

Other