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Cystic Fibrosis

 Syn. Fibrocystic disease , CF , Cystic fibrosis of the pancreas

Signs & Symptoms

 Pancreatic insufficiency
Note: due to obstruct pancreatic ducts, Tenacious exocrine secretions that obstruct pancreatic ducts and impair production and flow of digestive enzymes
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]
Family history of cystic fibrosis in sibling #Criteria
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]
Aquagenic wrinkling of the palms
Note: Wrinkling and nodules that develop after several minutes of immersion in water
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]
Persistent pulmonary infection
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]

Physical Examination

 Edema
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]
Transepithelial potential difference #Criteria
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]
Abnormal nasal potential difference #Criteria
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]

Lab / Serology

 Hypoproteinemia
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]
Electrolyte loss
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]
Anemia
Note: due to malabsorption, due to blood loss
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]

Imagin Study

 Panopacification of the paranasal sinuses
Note: due to Sinus disease
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]
Chronic pansinusitis
Ref: Harrison [ 1986]
Hyperechogenic bowel Gr. Prenatal #Criteria
Note: Prenatal presentation
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]

Complication

 Pancreatic insufficiency
Note: due to obstruct pancreatic ducts, Tenacious exocrine secretions that obstruct pancreatic ducts and impair production and flow of digestive enzymes
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis] Harrison [ 1986]
Bronchiectasis
Note: due to Infection of the airways
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]
Chronic bronchitis
Note: Chronic bronchitis with typical organisms
Ref: Uptodate [ Cystic fibrosis: Clinical manifestations and diagnosis]

Risk Factors

 White race
Ref: Harrison [ 1988]
Caucasians
Ref: Harrison [ 1986]

Cause

Other