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Hyperparathyroidism

Signs & Symptoms

 Isolated hyperparathyroid gland adenoma
Ref: Harrison [ 2925] Cecil [ 742]
Depression
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
Anorexia
Note: due to Hypercalcemia
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
Recurrent nephrolithiasis
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations] Harrison [ 2925] Cecil [ 742]

Physical Examination

 Changes in mental status
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
High body mass index
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
Muscle atrophy
Ref: Harrison [ 2927]

Lab / Serology

 Increased serum chloride
Ref: Cecil [ 742]
Reduced serum bicarbonate
Ref: Cecil [ 742]
Mild hypercalcemia
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations] Harrison [ 2925] Cecil [ 742]

Imagin Study

 Subperiosteal bone resorption
Note: due to Osteitis fibrosa cystica
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations] Harrison [ 2927]
Tapering of the distal clavicles
Note: due to Osteitis fibrosa cystica
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
Bone cysts
Note: due to Osteitis fibrosa cystica
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]

Complication

 Impaired glucose tolerance
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
Anxiety
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]
Psychosis
Ref: Uptodate [ Primary hyperparathyroidism: Clinical manifestations]

Risk Factors

 Age between 30 and 50
Ref: Harrison [ 2925]

Cause

 Isolated hyperparathyroid gland adenoma
Ref: Harrison [ 2925] Cecil [ 742]
MEN syndrome
Ref: Harrison [ 2925]

Other