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Rheumatoid Arthritis

 Syn. RA , Chronic rheumatic arthritis

Signs & Symptoms

 Interphalangial joints of the thumbs tenderness
Note: Early dx manifestation
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]
Wrist tenderness #Criteria
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]
Wrist warmness #Criteria
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]
Wrist pain #Criteria
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]

Physical Examination

 Small hand joints tenderness
Note: Early dx manifestation
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013] Harrison [ 2529]
Interphalangial joints of the thumbs tenderness
Note: Early dx manifestation
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]
Wrist tenderness #Criteria
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]

Lab / Serology

 Positive Anti-citrullinated peptide antibodies
Ref: Harrison [ 2535] Cecil [ 771]
Positive Anti-citrullinated protein antibodies #Criteria
Ref: Harrison [ 2535] Cecil [ 771]
Elevated WBC in synovial fluid
Note: 1500-25000 wbc, due to inflammatory effusion
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013] Harrison [ 2535]

Imagin Study

 Knee effusion
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]
Osteopenia in xray
Ref: Harrison [ 2535]
Synovial thickening of the knee
Note: Extends to patella
Ref: Uptodate [ Clinical features of rheumatoid arthritis 2013]

Complication

 Hematologic abnormality
Ref: Harrison [ 2529] Cecil [ 772]
Flat feet
Note: due to chronic inflammation of the ankle, due to chronic inflammation of midtarsal
Ref: Harrison [ 2528]
Hypoandrogenism
Ref: Harrison [ 2530]

Risk Factors

 Smoking
Ref: Harrison [ 2531]
Obesity
Ref: Cecil [ 770]

Cause

Other