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Acute Fatty Liver Of Pregnancy

 Syn. AFLP

Signs & Symptoms

 In third trimester
Note: differ from From hyperemesis gravidarum in first trimester
Ref: Uptodate [ Acute fatty liver of pregnancy]
Nausea
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Vomiting
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Abdominal pain
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]

Physical Examination

 Jaundice
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Signs of preeclampsia
Note: Proteinuria hypertention edema
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Hypertention
Note: Signs of preeclampsia
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]

Lab / Serology

 Proteinuria
Note: Signs of preeclamsia
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Increased bilirubin
Note: Less common in preeclampsia
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Serum aminotransferase elevations
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]

Imagin Study

 Hepatic infarct (negative symptom)
Ref: Uptodate [ Acute fatty liver of pregnancy]
hepatic hematoma (negative symptom)
Ref: Uptodate [ Acute fatty liver of pregnancy]

Complication

 Hepatic encephalopathy
Note: In most severe cases
Ref: Beckman [ 463]
Elevated ammonia
Note: due to hepatic insufficiency
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]
Long PT
Note: due to hepatic insufficiency
Ref: Uptodate [ Acute fatty liver of pregnancy] Beckman [ 463]

Risk Factors

Cause

Other