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Pancreatic Cancer

 Syn. Carcinoma of pancreas , Pancreatic carcinoma

Signs & Symptoms

 Anorexia #Advanced
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer] Cecil [ 436]
Gnawing
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer]
Intermittent pain
Ref: Uptodate [ intermittent]
Abdominal pain
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer] Harrison [ 593] Cecil [ 436]

Physical Examination

 Weight loss #Advanced
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer] Harrison [ 593] Cecil [ 436]
Asthenia
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer]
Jaundice #Obstructive_CBD
Note: first detectable with a bilirubin of 2.5–3.0 mg/dL
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer] Harrison [ 593] Cecil [ 599]

Lab / Serology

 Malabsorption
Ref: Epocrates [ https://online.epocrates.com/diseases/26531/Pancreatic-cancer/Diagnostic-Approach]
Hypercalcemia
Ref: Cecil [ 436]
Elevated CA125
Note: can be positive when the CA19-9 is negative due to the patient not being a Lewis antigen secretor
Ref: Harrison [ 594]

Imagin Study

Complication

 Palpable periumbilical mass #Metastatic
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer] Harrison [ 593]
Left supraclavicular lymphadenopathy #Metastatic
Note: Signs of late disease
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer] Harrison [ 593]
Palpable rectal shelf #Metastatic
Note: widespread disease
Ref: Uptodate [ Clinical manifestations, diagnosis, and staging of exocrine pancreatic cancer]

Risk Factors

 Chronic Pancreatitis
Ref: Uptodate [ Clinical manifestations and diagnosis of chronic pancreatitis in adults] Unknown [ 0]
Cigarette smoking
Ref: Unknown [ 0]
Physical inactivity
Ref: Unknown [ 0]

Cause

Other