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Extrahepatic Cholestasis

 Syn. Extrahepatic Bile Duct Obstruction , Extrahepatic obstructive biliary disease , Bile Duct Obstruction, Extrahepatic

Signs & Symptoms

 Pruritus
Ref: Cecil [ 448-451]
Right upper quadrant discomfort #Choledocholithiasis
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests]

Physical Examination

 Jaundice #Choledocholithiasis #ascending_cholangitis
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests]

Lab / Serology

 Associated with hypercholesterolemia
Ref: Harrison [ 2897]
Hypertriglyceridemia
Ref: Harrison [ 2897]
Hyperlipoproteinemias
Ref: Harrison [ 2897]

Imagin Study

 Ultrasound demonstrate presence of biliary dilatation
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests] Harrison [ 280]

Complication

 Circulatory collapse #Choledocholithiasis #ascending_cholangitis
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests]
Sepsis #Choledocholithiasis #ascending_cholangitis
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests]

Risk Factors

 Gallstones
Ref: Unknown [ 0]

Cause

 Caused by mechanical obstruction to the flow of bile through bile ducts
Ref: Cecil [ 446]
Caused by Choledocholithiasis
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests]
Caused by pancreatic cancer
Ref: Uptodate [ Approach to the patient with abnormal liver biochemical and function tests]

Other