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Paraneoplastic Syndromes

 Syn. Paraneoplastic Syndrome

Signs & Symptoms

 Severe watery diarrhea
Note: due to secretion of peptides that cause intestinal secretion
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]

Physical Examination

 Confusion
Note: due to severe reductions in plasma glucose, due to severe Hypoglycemia
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]
Lethargy
Note: due to severe reductions in plasma glucose, due to severe Hypoglycemia
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]

Lab / Serology

 Erythrocytosis
Note: due to tumor secretion of erythropoietin, due to tumor secretion of EPO
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]
Hypercalcemia
Note: due to secretion of parathyroid hormone-related protein, associated with osteolytic metastases
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]
Hypoglycemia
Note: due to tumor's high metabolic needs
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]

Imagin Study

Complication

 Achlorhydria
Note: due to severe Watery diarrhea
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]
Confusion
Note: due to severe reductions in plasma glucose, due to severe Hypoglycemia
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]
Hypokalemia
Note: due to severe Watery diarrhea
Ref: Uptodate [ Clinical features and diagnosis of primary hepatocellular carcinoma]

Risk Factors

Cause

Other